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How to Fix Your Gut Bacteria to Prevent Heart Attacks with Dr. Stanley Hazen

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There’s a lot more happening in your gut than you might think. Sure, our digestive system moves food through the body, extracting nutrients and eliminating waste. But there’s actually a significant portion of calories we ingest that don’t get absorbed and instead are used to feed our gut bacteria. This inner microbiome creates its own type of waste: metabolites that can be absorbed into the bloodstream and pumped throughout the rest of the body.

We’re finding some of these compounds can impact everything from obesity and diabetes to blood pressure and heart disease—it’s astounding to realize the far-reaching effects on whole-body health that all start within the gut.

Today’s guest on The Doctor’s Farmacy is here to explain that connection on a deeper level. Dr. Stanley Hazen is both the chair of the Department of Cellular & Molecular Medicine at the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation at the Heart and Vascular Institute of the Cleveland Clinic. He’s published more than 400 peer-reviewed articles and has over 50 patents from his pioneering discoveries in atherosclerosis and inflammatory disease. Dr. Hazen made the seminal discovery linking microbial pathways to the pathogenesis of cardiovascular disease, which we talk much about in this fascinating episode.

Tags: gut health, microbiome, health, heart health, heart attack, dr. stanley hazen, dr. mark hyman, mark hyman, podcast, the doctor’s farmacy

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Dr. Hyman is an 11-time New York Times bestselling author, family physician and international leader in the field of Functional Medicine. His podcast, The Doctor's Farmacy, is a place for deep conversations about the critical issues of our time in the space of health, wellness, food and politics. New episodes are released every Wednesday here on YouTube, and wherever you listen to podcasts.

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38 Comments on How to Fix Your Gut Bacteria to Prevent Heart Attacks with Dr. Stanley Hazen

  1. Can one still claim that cholesterol is causing cvd?

    • Did this doc do it?

    • yes

    • The body need fats to help the heart. No fat no HEART.eat more greed fed meats.

    • I like the argument of correlation vs causation. Sure, cholesterol is involved in heart disease but to say it causes heart disease is like saying that water causes drowning. I’ll be glad when this whole “cholesterol causes CVD” crap is finally laid to rest. Too much money to be made by big pharma yet for that to happen in my “cholesterol shortened” lifetime.

  2. Thank you so much for these conversations!

  3. Jim Battaglia // 2nd January 2019 at 12:53 pm // Reply

    Great questions but the answers were not really specific. I did notice that he was focusing on a drug to help with managing the tmao. Yet he said at one point “pills form mess things up.” The body is self healing and regulating so why we keep introducing pills as the answer? I getting tired of them mentioning Cholestrol causing heart issues. If you see a fire truck at a house fire do we assume the fire truck cause the fire?

  4. A great video. I am a herbalist and vegetarian over 30yrs years. I have Dr Hyman books and enjoy his info. Thanks for having people with the information.

  5. We learn from each other even if you think you know. Knowledge is powerful especially for your health. Without health you can’t do anything work, feed yourself, or wipe your own butt. Stay healthy!!

  6. This seems like by vegetarian propaganda.

  7. Treasure Hunting Pro // 2nd January 2019 at 1:45 pm // Reply

    How’s it going Mark..good videos keep going.

  8. Eujanio Coutinho // 2nd January 2019 at 1:51 pm // Reply

    Ketogenic is the best. Veganism is moronism

    • Vegan bias goes: The kidneys are not clearing out enough tmao, which means high tmao. High tmao is linked with cvd. Case closed, eat less meat, build and market a tmao inhibitor…. Reality: the kidneys aren’t clearing tmao due to insulinemia, which causes high blood pressure, inflammation, and Atherosclerosis. Which is caused by carbs, ultimately PLANTS…. This should be evident since choline, tmao precursors, are found in fish, anti atherosclerotic! Also, gout, Alzheimer’s and other diseases would be associated with no tmao. Carnitine and cla are used to shred body fat, which will improve 95 percent of adult health, adding decades to life…. Also, not all studies show tmao and cvd link-likely those that understood the kidney, insulinemia link.

  9. This guy does not look healthy

  10. Graham Crawford // 2nd January 2019 at 2:15 pm // Reply

    Why should I believe this guy when the last guy said eat animal products and that it’s carbohydrates and insulin resistance which triggers heart disease?????????? Ffs!!!

    • Judy Peterson // 2nd January 2019 at 5:50 pm // Reply

      Go KETO!!!!!!!!!

    • What we can determine from this guy is that many factors are at play with poor health and good health. No one way, people are complicated. The take away is yet another piece of puzzle, whole foods, exercise.

    • The kidneys are not clearing out enough tmao, which means high tmao. High tmao is linked with cvd. Case closed, eat less meat, build and market a tmao inhibitor…. Reality: the kidneys aren’t clearing tmao due to insulinemia, which causes high blood pressure, inflammation, and Atherosclerosis. Which is caused by carbs, ultimately PLANTS…. This should be evident since choline, tmao precursors, are found in fish, anti atherosclerotic! Also, gout, Alzheimer’s and other diseases would be associated with no tmao. Carnitine and cla are used to shred body fat, which will improve 95 percent of adult health, adding decades to life…. Also, not all studies show tmao and cvd link-likely those that understood the kidney, insulinemia link.

  11. Not all studies have demonstrated an association between TMAO and atherosclerotic vascular disease. Mueller et al. measured plasma concentrations of TMAO, betaine and choline in a cohort of 339 patients undergoing coronary angiography and noted that plasma concentrations of TMAO were higher in diabetics compared to euglycemic patients [35]. The plasma levels of TMAO or betaine were not found to be associated with a history of myocardial infarction, the angiographically-assessed presence of coronary heart disease, or the incident cardiovascular events during 8 years of follow-up. In a case-control study of patients with large-artery atherosclerotic ischemic stroke and transient ischemic attack, participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased [36].
    Although elevated plasma levels of TMAO have been associated with atherosclerotic vascular diseases and increased risk of adverse cardiovascular events, seafood, which contains high levels of TMAO, is generally considered beneficial for health. Another contradictory finding was reported by Bjørnda et al. who demonstrated that feeding male Wistar rats a phospholipid-protein complex (PPC) from Antarctic krill increased the plasma levels of TMAO, choline, and carnitine. However, there was no correlation between plasma choline and TMAO in rats fed PPC.

    So, diabetes causes kidney damage and Atherosclerosis. The kidneys don’t clear tmao. Thus tmao is associated with high cvd.

  12. Loved the discussion, full of new ideas for me to investigate and possibly implement. We each get to “vote” on whether we agree by eating as we choose.

  13. Graham Crawford // 2nd January 2019 at 4:37 pm // Reply

    So basically the doc wants everyone to be able to afford his new drug????

  14. Cary Skelton Pitman // 2nd January 2019 at 5:30 pm // Reply

    It’s quite possible, the negative folks on this thread may need their microbiome evaluated. Knowledge is power. Not one nutrition plan will work for all. Thank you Dr. Hyman and Dr. Hazen for sharing your insights. Cheers to a healthy, happy and peaceful 2019.

    • Eat raw fermented foods and you will be OK.

    • The kidneys are not clearing out enough tmao, which means high tmao. High tmao is linked with cvd. Case closed, eat less meat, build and market a tmao inhibitor…. Reality: the kidneys aren’t clearing tmao due to insulinemia, which causes high blood pressure, inflammation, and Atherosclerosis. Which is caused by carbs, ultimately PLANTS…. This should be evident since choline, tmao precursors, are found in fish, anti atherosclerotic! Also, gout, Alzheimer’s and other diseases would be associated with no tmao. Carnitine and cla are used to shred body fat, which will improve 95 percent of adult health, adding decades to life…. Also, not all studies show tmao and cvd link-likely those that understood the kidney, insulinemia link.

  15. Judy Peterson // 2nd January 2019 at 5:53 pm // Reply

    I had to get past the pro-evolution garbage to try to honestly evaluate this discussion! Can I trust the knowledge of people who obviously understand the GREAT complexity of the human body but then ignorantly believe we evolved?????????

    • Health without doctors // 2nd January 2019 at 8:32 pm // Reply

      we do evolve dude…evolution doesn’t exclude existence of god. Well, mostly do evolve, Detroit…not that much hahahaha. Actually human body evolves, what we are, energy, doesn’t as perfect can’t get better but human body, yeah, it learns from experience so evolution is valid. Then again…Detroit….

    • Please don’t work too hard to get past the pro-evolution stuff. This information could extend life and the last thing we need is evolution denialists living a long time.

  16. I appreciate the perspectives you share. It’s easy to only feature guests that reinforce your point of view. Now can I stop drinking Kombucha…lol but yuck

  17. My Weight gain did NOT come first~!!! But have been on Anti-Biotics almost all my life~!!! I think it ALL Depends on the Microbiome~~~!!!!

  18. I don’t know who said it first, but nothing that we suffer from is a pharmaceutical deficiency disease. Except in the case of a life-saving triage situation, drugs for the most part deal with symptoms which are a part of your body’s natural processes. There’s a reason why your BP is high, there’s a reason why your cholesterol is though the roof and there’s a reason why your joints ache…and you can control all of it through lifestyle changes but that’s hard and insurance doesn’t cover it.

    • Correct. The body will heal with the food that comes from nature. It was what we were designed to eat. You can get a strong microbiome by eating both prebiotic foods (vegetables) and probiotic foods (fermented foods: kefir, kombucha, fermented vegetables). Plant-based is not vegan or even vegetarian. It is mostly plants with some meat, fish, and animal-based foods. https://www.culturedfoodlife.com

    • Health without doctors // 2nd January 2019 at 8:26 pm // Reply

      is hard because people are morons who would rather trust some loser in white coat that makes money off you if you’re sick not healthy…go figure…they all learn in time, by age 50 everyone relaizes medical system is a scam and health is an illusion they sell for good money. Nobody heals you, not your doc, not you, not your god, nobody but your immune system. Cut the bad, food, people, places, load on fruits, you can’t go wrong. all passing age of 90 have something in common: no hospital visits except last time when they croak…and only because their stupid relatives thought high blood pressure must be checked by an Md hahahahha

  19. Health without doctors // 2nd January 2019 at 8:29 pm // Reply

    I don’t know who’s more evil, the medical or the food industry? Tsk tsk tsk…very hard to choose…god better enlarge hell for besides lawyers, car salesmen and army recruit, docs and commercial food makers are making a run for it hahahaha

  20. thestratford51 // 2nd January 2019 at 8:31 pm // Reply

    This is unfortunately for me a highly disappointing episode. Dr. Hazen advised viewers to eat a mediterranean diet which typically means including grains such as pasta and bread. Dr. Hazen’s study also fails to make a differentiation between factory-farmed meats (GMO grain feed, antibiotics and growth hormones, animals in crammed, filthy environments etc.) versus pasture-raised organic grass-fed grass-finished meat from small family farms . First he guides viewers to consuming foods that can be harmful to our bodies and then he tell us he is working with the pharmaceutical industry to develop more pharmaceutical drugs, to purport to deal with a problem that may be caused by consuming the very foods that he recommended. Not 55 minutes of well spent time watching this, unfortunately. Sigh.

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