Age is not the definitive factor it’s made out to be when it comes to our health. We can use our age as a baseline for tracking our health and longevity, but it isn’t stagnant. For example, certain types of testing can help us compare our biological age to our calendar age in order to tinker with our wellness routine and achieve the milestones we’re after. With the right steps, we can slow down and even sometimes reverse the aging process.
When it comes to our biological age, or the measure of how well our body is actually functioning for whatever life stage we are in, there are many things that impact it. Diet, lifestyle patterns like exercise and sleep, and stress are all involved in forming our biological age, along with many other factors like blood sugar, inflammation, and genetics. This week on The Doctor’s Farmacy, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. Dr. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects.
This episode of The Doctor’s Farmacy is brought to you by ButcherBox. Now through September 29, 2019, new subscribers to ButcherBox will receive ground beef for life. When you sign up today, ButcherBox will send you 2lbs of 100% pasture-raised grass-fed, grass finished beef free in every box for the life of your subscription. Plus listeners will get an additional $20 off their first box. All you have to do is head over to ButcherBox.com/farmacy
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Dr. Hyman is an 11-time New York Times bestselling author, family physician and international leader in the field of Functional Medicine. His podcast, The Doctor's Farmacy, is a place for deep conversations about the critical issues of our time in the space of health, wellness, food and politics. New episodes are released every Wednesday here on YouTube, and wherever you listen to podcasts.
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Amazing information I did it though diet. Keto
Dr. Sinclair could benefit from having you manage his health. Four hours on Sunday at the gym? To make up for lost gym time? No side effects of metformin? I’m currently looking at Dr. Que Collins’ opinion on supplements- don’t take them. Admittedly I’m just looking at that… I still do supplements.
Alpha lipoid acid… good stuff.
what about niacin instead of statins
and berberine instead of metformin
Although I am obviously not David himself, if that’s whom you were asking, I would like to point out that the drugs you’ve listed are not fully interchangeable and/or equipotent. A big part of the niacin MOA (i.e. mechanism of action) relies on activation of the so-called niacin receptors. On the other hand, statins function as inhibitors of an enzyme that leads to cholesterol production, namely HMG-CoA reductase. Metformin and berberine are somewhat alike, given their shared ability to activate AMPK; however, metformin has been used and studied for over half a century, whereas berberine is relatively understudied (of course, there’s no real incentive for pharmaceutical companies, especially since metformin has such an amazing safety profile and is so cheap). For instance, berberine has been reported to inhibit cytochromes P450, so it could affect metabolism of drugs and lead to their elevated blood levels.
My point is, if you want to have the benefits of metformin, I’d personally try to get metformin. Either way, » use the right tool for the job «, and know what you’re doing. And consult your doctor, particularly if you plan to combine various drugs, or e.g. you’re taking a statin and trying to replace it with niacin unsupervised.
Take care.
@AMP-activated protein kinase I dont have cholesterol or blood sugar problems. I do need a safe easy way to increase my iron though! I dont think meat or supplements are the answer. I havent found a great solution yet! If you have the answer I would be grateful!
@Sparleberry …….a Copper deficiency may cause iron deficiency anemia.
@soupper soulger thanx! i take a zinc/ copper supplement but I guess I need testing. A vegetarian diet doesnt help either!
Maybe I should cut the zinc/ copper supplement and see what happens, but I dont want my thyroid going downhill!
Lost me on the plants but still agree with 90% but you can’t agree with everything in life this creates balance. I started with Keto now switched to carnivore started very unhealthy at 62 years old 268 lbs now 147 lbs and reversed much of my ailments. It’s all experimental. on your own body I’m happy so far.
quit interrupting the through process.
Hyman, please stop the jokes and let the visitor talk.
Amen – he is into the social aspects of the interviews since he knows these guys. But it gets distracting when he starts joking and going down rabbit holes. He’s got great contacts in his network. Just wish he’d let them free-wheel more and just chill.
Thank you
David Sinclair is nothing short of genius and gift to humanity in my opinion (and from my research). Thank you Dr Mark your show is inspiration to many. I wonder what both your thoughts are on what is also an emerging science, the role our thoughts, feelings / emotions and beliefs play in regulating gene expression / health? These 2 theories combined (how to enhance the mechanical body for optimum performance and health and longevity) coupled with how to ‘consciously’ (I use that word very purposefully) pursue health choices, seems to me to be progressional evolutionary path?. Exciting time to be alive. Very grateful for your work.
Martin Smith I so agree! Health was great until four years. Last few years so many negative thoughts and feeling defeated. Never been in as poor health.
It is disappointing that Sinclair is going the “pharmaceutical” route with NMN.
Why? It’s certainly the proper route for pharmaceuticals meant to be used potentially by tens, or hundreds of millions of people, in the long run… Check the story of thalidomide.
AMP-activated protein kinase I am not saying FDA process is not important although it could be made more efficient and less profit driven. It’s the time it takes to get through FDA approvals and the cost which drives up treatment cost.
No one wants another thilodimide tragedy but take for example Navacims. A potential cure for most autoimmune diseases that could literally eradicate the suffering of millions. It was discovered 15 YEARS AGO and just now going through human clinical trials. Just this year, it has been individually licensed to two companies for nearly $1 Billion each license for the development of just a few of the most profitable (diabetes, IBD, and arthritis). Meanwhile many other devastating autoimmune diseases like MS, Lupus, and about a hundred more are waiting for another company to step up and pay the next billion dollar licensing fee to develop their drug on this ground breaking platform.
I reiterate that this is not being researched as just another treatment but an outright cure. It will probably be another 5 years before even the first drug hits the market. It shouldn’t take 20 years for a drug to come to market. That’s 20 years of unnecessary suffering and death.
FDA process is necessary for platforms like Navacims but why take something that is basically a form of vitamin B3 (niacin) that is only patentable because of how it’s produced through an extensive FDA process?
Great info. Thanks. I am going to get Dr. Sinclair’s Book “Lifespan – Why We Age and Why We Don’t Have To”.
Why are you both being so darn vague? We listen to these podcasts for actionable information. What protocol did Dr. Hyman use to recover from his CFS? What are the “and some other stuff” he spoke about in his wife’s protocol? Other than NMN, NR and resverotrol, what other molecules is Sinclair talking about?
Dr. Sinclair seems that he uses Botox to keep look younger, nothing against Botox but it seems controversial….
what is the yogurt he likes?
Bravo brand is what he said in another video.
@Loki whispers Thanks!
Imressive..whether it works or not. for sure a step forward …Hyman, Sinclair, Longo, Panda, Patrick and 5 others are amagzingresearchers that should be appreciated by all…
Mark you’re so handsome. You don’t look your age either.
Questioned much of what they discussed – prefer a more holistic, diet based approach than taking chemicals. When he disclosed that he takes a statin as he is “concerned about his cholesterol”; I turned off the video. Cholesterol is both healing and necessary for our bodies – studies have shown that those with the highest cholesterol levels actually live the longest…
Please tell me about the rings that collected data you both are wearing & who processes the information collected?
Please tell me about the rings that collected data you both are wearing & who processes the information collected?